In this game — which features Wolverine, Magneto, Cyclops, Iceman, Psylocke, the Sentinels and more — each player fields a superhero team, with each hero being represented by custom-tooled dice; each team must be composed of 15 dice, and a player can purchase dice only from his team. Each hero also has one or more character reference cards, which show the special abilities for the characters based on the die rolls. Different versions of these cards will be available in booster packs, allowing for more customization of your team. Players use these dice to collect energy, recruit new heroes, and battle head-to-head. In addition, each player brings two basic action cards to the game, which are placed in the center of the table; both players can purchase these cards. A player wins once the opposing player has been reduced to zero life.

The Marvel Dice Masters: Uncanny X-Men starter set comes with 44 custom dice, 38 cards, two dice bags, and a core rulebook. Booster packs include two dice with two matching character cards.